Our Mission: Enhance Apoptosis Escape

Smart Growth Factor™ technology enhances Apoptosis Escape through targeted activation of the IGF-1 signaling pathway. Our lead program, scp776, mitigates damage in preclinical models of stroke, heart attack, and kidney injury, and is safe in Phase 1 studies.

Our Mission: Enhance Apoptosis Escape

Smart Growth Factor™ technology enhances Apoptosis Escape through targeted activation of the IGF-1 signaling pathway. Our lead program, scp776, mitigates damage in preclinical models of stroke, heart attack, and kidney injury, and is safe in Phase 1 studies.

Cell Fate During Acute Injury

During acute injury, cells have 3 fates: survival, apoptosis, or necrosis. Some injured cells can naturally avoid cell death via a mechanism called Apoptosis Escape. Enhancement of Apoptosis Escape after an acute injury leads to improved cell survival and preserved organ function. Growth factors have the potential to promote cell and tissue survival by enhancing Apoptosis Escape.

The Challenge: Delivering IGF-1 to Injured Tissue

IGF-1 enhances Apoptosis Escape through well-characterized, pleiotropic mechanisms. However, natural IGF-1 is rapidly captured by IGF binding proteins (IGFBPs) which precludes effective delivery to injured cells. Increasing the dose of IGF-1 to reach the injured tissue results in an unacceptable side effect profile.

The Solution: Smart Growth Factors

Our lead program, scp776, demonstrates the power of Silver Creek’s Smart Growth Factor™ platform. Scp776 is a novel fusion protein that enhances Apoptosis Escape in injured tissues through IGF-1 signaling, while overcoming the limitations of natural growth factor therapeutics. Scp776 selectively targets pro-survival signaling to the apoptotic cells during acute injury, efficiently mitigating damage while avoiding adverse off-target effects.

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